Hyaluronic Acid

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Antibiotics loaded into hyaluronic acid hydrogels did not harm bone cells at clinical doses and effectively inhibited Staphylococcus aureus. Cefuroxime was released faster than vancomycin, suggesting the hydrogel could be used to treat implant-related infections in orthopedics.

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Peptide–drug conjugates with gold nanoparticles in a hyaluronic acid hydrogel achieved strong tumor suppression in breast cancer when combined with heat and chemotherapy. The system released drug in response to tumor acidity and could be activated with light for localized treatment.

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Collagen scaffolds with heparin promoted muscle cell growth and differentiation better than those with hyaluronic acid or chondroitin sulfate. Heparin also trapped more IGF-1, a key growth factor, highlighting how scaffold chemistry can be tuned for muscle tissue engineering.

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Patients with obstructive jaundice had higher blood levels of shed glycocalyx components—hyaluronic acid, chondroitin sulfate, and syndecan-1—and increased vascular permeability. Protecting the glycocalyx may offer a way to improve outcomes around surgery in these patients.

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Manganese oxide nanoparticles coated with hyaluronic acid and the mitochondria-targeting peptide SS31 reduced kidney damage and improved survival in mice with ischemia-reperfusion injury. Delivering antioxidants to mitochondria may help break the cycle of oxidative stress and inflammation in acute kidney injury.

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The 7S domain of type IV collagen was evaluated as a noninvasive marker for portal hypertension and high-risk varices in liver disease. The work aims to identify a reliable blood test alternative to invasive pressure measurement.

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A hyaluronic acid–cinnamic acid conjugate improved diarrhea, gut sensitivity, and barrier function in a mouse model of IBS-D by modulating serotonin signaling and gut bacteria. The compound delivered more cinnamic acid to the colon than free cinnamic acid alone, suggesting a potential new treatment for IBS-D.

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Nanoparticles carrying a peptide that blocks CD154–CD11b binding, when combined with CTLA-4Ig, prolonged skin graft survival in mice and reduced donor-reactive T cells. Some mice treated for 100 days developed lasting tolerance without further immunosuppression.

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Soluble antigen arrays built on hyaluronic acid and displaying type 1 diabetes autoantigens engaged human T cell clones with high specificity. The platform could support targeted immunotherapy for type 1 diabetes without broad immunosuppression.

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IL-10 was encapsulated in peptide nanocrystals and released slowly over about a month, protecting the cytokine from degradation. When embedded in gelatin–hyaluronic acid or PHBV matrices, the system reduced inflammation in cell culture and could support treatment of inflammatory skin conditions.

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A carbon monoxide–releasing platform using hyaluronic acid to target microglia reduced inflammation, eased hypoxia, and protected neurons in a spinal cord injury model. The system releases CO in response to reactive oxygen species, offering a potential therapy for neurotrauma.

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A poly-lysine and hyaluronic acid coating on implant materials killed bacteria on contact and reduced bacterial adhesion by up to 5 logs without harming bone cells. The coating could help prevent prosthetic joint infections without relying on antibiotics.

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Liraglutide loaded into silica nanoparticles coated with a cell-penetrating peptide and hyaluronic acid was absorbed orally in diabetic rats, lowering blood sugar and body weight comparably to injected liraglutide. The approach could enable non-injectable delivery of peptide drugs.

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Medical fabric coated with polyarginine and hyaluronic acid reduced bacterial load by at least 6 logs and prevented biofilm formation in wound infection models, including MRSA. The antibiotic-free coating could help prevent wound infections and combat resistant bacteria.

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Hydrogels combining peptide gelators with graphene oxide functionalized with hyaluronic acid enabled controlled release of HA for osteoarthritis treatment. The nanocomposites aim to support cartilage repair and reduce inflammation while mimicking the mechanical environment of joint tissue.

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Different molecular weights of hyaluronan had distinct effects in a rat model of acute respiratory distress syndrome, with mixed-weight HA providing the best improvement in lung structure and function. The results suggest HA-based strategies could be tailored for ARDS treatment.

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Serum soluble ASGR1 was higher in patients with fatty liver disease and linked to adiponectin. The work explores whether this receptor could serve as a biomarker or target in metabolic liver disease.

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A hyaluronic acid–glucose hydrogel that releases glucose when enzymes cleave it helped stem cells survive and function in low-glucose conditions. The stem cell secretome from this hydrogel improved chondrocyte growth and reduced inflammation, suggesting a potential treatment for osteoarthritis.

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Hyaluronic acid–coated nanoparticles carrying doxorubicin delivered drug selectively to tumor cells, where glutathione triggered release and fluorescence. In mice, the system reduced tumor volume fivefold compared to saline and twofold compared to free drug, with minimal toxicity.

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A modified proinsulin antigen on a hyaluronic acid backbone targeted anti-insulin B cells without affecting blood sugar. The approach could support antigen-specific immunotherapy for type 1 diabetes while avoiding hormonal side effects.

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An injectable hydrogel that crosslinks with calcium in the joint reduced inflammation, scavenged reactive oxygen species, and improved arthritis scores in rats, outperforming dexamethasone. The natural components—hyaluronic acid, alginate, and paeoniflorin—support its potential for clinical use in rheumatoid arthritis.

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Exosomes engineered to target cartilage and loaded into hyaluronic acid microspheres promoted cartilage repair and slowed osteoarthritis progression in mice. The system retained exosomes in the joint longer and improved cartilage scores, suggesting a promising strategy for OA treatment.

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Antibodies fused to an hyaluronic acid–binding domain stayed in the brain longer after injection into the ventricles, improving exposure compared to unmodified antibodies. The approach could help develop more effective antibody therapies for brain and spinal cord disorders.

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Dissolvable microneedles made from hyaluronic acid and polyvinyl alcohol delivered capsaicin-loaded nanomicelles through the skin, reducing fat mass and promoting fat browning in obese mice. The protocol offers a minimally invasive way to deliver hydrophobic compounds for obesity management.

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Coating mesenchymal stem cells with a hyaluronic acid–based matrix that mimics fibrotic tissue boosted their ability to break down collagen and reduce scarring in a heart attack model. The approach could improve cell-based therapies for fibrotic diseases.

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Gynostemma pentaphyllum extract and its bioactive compound Damulin B reduced UV-induced wrinkles, preserved collagen and hyaluronic acid, and improved skin hydration in mice. The effects were linked to lower oxidative stress and restored signaling pathways that maintain skin structure.

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A gelatin–hyaluronic acid hydrogel loaded with polydopamine-coated cerium dioxide killed bacteria under near-infrared light and shifted macrophages toward a healing phenotype. In infected wounds, the combined treatment achieved over 95% healing by day 15.

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Egyptian experts reached consensus on which dermocosmetic ingredients to use in common skin scenarios for Fitzpatrick skin types III–V. The recommendations provide guidance for populations often underrepresented in existing guidelines.

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Crocin reduced liver fibrosis in rats by targeting inflammatory and fibrotic pathways, including NF-kappaB and TGF-beta. The work explores whether this plant compound could support recovery from liver scarring.

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FGF23 bound to hyaluronic acid, chitosan, and other charged polymers with different strengths, and desorbed more easily from negatively charged surfaces. The findings inform design of carriers and materials for FGF23-related therapies.