CJC-1295 with DAC
Also known as: CJC-1295 with DAC
The long-acting version of CJC-1295. After injection it attaches to a protein in your blood (albumin), which keeps it active for nearly a week instead of just 30 minutes. This means you only need to inject once a week. The trade-off is that it keeps growth hormone elevated constantly rather than in natural pulses, which some practitioners consider less ideal for your body. More convenient but potentially less natural than the no-DAC version.
Dosage
1-2 mg subcutaneous once weekly
Dosages shown are for research reference only. Always consult a qualified healthcare provider.
Administration
Subcutaneous injection (weekly)
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Effects
Sustained GH Elevation
Week-long half-life provides continuous growth hormone stimulation.
Muscle Growth
Sustained GH elevation supports anabolic processes.
Fat Loss
Sustained GH elevation promotes ongoing fat metabolism.
Mechanism of Action
CJC-1295 with DAC shares the same core peptide sequence and GHRH receptor binding mechanism as the no-DAC version — it activates Gs/adenylyl cyclase/cAMP/PKA signaling in pituitary somatotrophs to stimulate GH synthesis and secretion. The critical difference is the Drug Affinity Complex (DAC), a reactive N-hydroxysuccinimide ester linker attached to the peptide that covalently and irreversibly binds to circulating serum albumin after injection.
Albumin is the most abundant plasma protein with a half-life of approximately 19 days. By permanently conjugating to albumin, the DAC moiety transforms CJC-1295 from a short-acting peptide (30-minute half-life) into a long-circulating molecule with a half-life of 6-8 days. The albumin-bound peptide continuously activates GHRH receptors as it circulates, producing a sustained elevation of GH levels rather than discrete pulses.
This sustained GH elevation is both the advantage and disadvantage of the DAC version. The convenience of weekly dosing is appealing, and total GH output over time may be higher. However, continuous GHRH receptor stimulation can lead to receptor desensitization (tachyphylaxis), and the loss of natural pulsatility may reduce the efficiency of GH signaling at target tissues. Somatostatin — the hypothalamic hormone that normally creates the troughs between GH pulses — is partially overridden by continuous receptor stimulation, which blunts the natural feedback regulation. Some practitioners also express concern that sustained GH elevation more closely mimics the pathological hormone profile of acromegaly than the healthy pulsatile pattern.
Regulatory Status
Not FDA approved. Available through compounding pharmacies. Some practitioners prefer the no-DAC version for more physiological pulsatile release.
Risks & Safety
Common
water retention/bloating, tingling and numbness in hands and feet, joint pain, headache, injection site reactions.
Serious
elevated cortisol, desensitisation from constant GH signal over time, reduced insulin sensitivity with prolonged use.
Rare
allergic reactions, significant swelling.
Compare CJC-1295 with DAC With
Research Papers
No research papers indexed yet. Papers are fetched from PubMed weekly.
Frequently Asked Questions
What is CJC-1295 with DAC?
The long-acting version of CJC-1295. After injection it attaches to a protein in your blood (albumin), which keeps it active for nearly a week instead of just 30 minutes. This means you only need to inject once a week. The trade-off is that it keeps growth hormone elevated constantly rather than in natural pulses, which some practitioners consider less ideal for your body. More convenient but potentially less natural than the no-DAC version.
What is CJC-1295 with DAC used for?
The long-acting version of CJC-1295. After injection it attaches to a protein in your blood (albumin), which keeps it active for nearly a week instead of just 30 minutes. This means you only need to inject once a week. The trade-off is that it keeps growth hormone elevated constantly rather than in natural pulses, which some practitioners consider less ideal for your body. More convenient but potentially less natural than the no-DAC version.
What is the dosage for CJC-1295 with DAC?
Standard: 1-2 mg subcutaneous once weekly. Lower dosing frequency than the no-DAC version due to extended half-life. Some protocols use every 5 days.
What are the side effects of CJC-1295 with DAC?
Common: water retention/bloating, tingling and numbness in hands and feet, joint pain, headache, injection site reactions. Serious: elevated cortisol, desensitisation from constant GH signal over time, reduced insulin sensitivity with prolonged use. Rare: allergic reactions, significant swelling.
How does CJC-1295 with DAC work?
CJC-1295 with DAC shares the same core peptide sequence and GHRH receptor binding mechanism as the no-DAC version — it activates Gs/adenylyl cyclase/cAMP/PKA signaling in pituitary somatotrophs to stimulate GH synthesis and secretion. The critical difference is the Drug Affinity Complex (DAC), a reactive N-hydroxysuccinimide ester linker attached to the peptide that covalently and irreversibly binds to circulating serum albumin after injection. Albumin is the most abundant plasma protein with a half-life of approximately 19 days. By permanently conjugating to albumin, the DAC moiety transforms CJC-1295 from a short-acting peptide (30-minute half-life) into a long-circulating molecule with a half-life of 6-8 days. The albumin-bound peptide continuously activates GHRH receptors as it circulates, producing a sustained elevation of GH levels rather than discrete pulses. This sustained GH elevation is both the advantage and disadvantage of the DAC version. The convenience of weekly dosing is appealing, and total GH output over time may be higher. However, continuous GHRH receptor stimulation can lead to receptor desensitization (tachyphylaxis), and the loss of natural pulsatility may reduce the efficiency of GH signaling at target tissues. Somatostatin — the hypothalamic hormone that normally creates the troughs between GH pulses — is partially overridden by continuous receptor stimulation, which blunts the natural feedback regulation. Some practitioners also express concern that sustained GH elevation more closely mimics the pathological hormone profile of acromegaly than the healthy pulsatile pattern.
How is CJC-1295 with DAC administered?
CJC-1295 with DAC is administered via subcutaneous injection (weekly).
What is the half-life of CJC-1295 with DAC?
The half-life of CJC-1295 with DAC is 144-192 hours (6-8 days).
Is CJC-1295 with DAC legal?
Not FDA approved. Available through compounding pharmacies. Some practitioners prefer the no-DAC version for more physiological pulsatile release.
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