Kisspeptin-54

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An intravenous kisspeptin bolus did not change vasopressin levels in healthy adults, so it does not appear useful as a provocative test for vasopressin deficiency. The lack of effect may be due to dose, route, or species differences.

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Lower KISS1 in decidual cells was linked to cesarean scar pregnancy, and restoring KISS1 increased cell invasion and migration via the PI3K/AKT pathway. The work suggests KISS1 helps balance trophoblast–decidua interactions and may be relevant to scar pregnancy.

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Kisspeptin-10 reduced triple-negative breast cancer cell growth and migration, reactivated KISS1, reversed EMT, and promoted apoptosis. The findings support exploring kisspeptin-10 as a treatment for this aggressive breast cancer subtype.

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Kisspeptin-54 reduced chondrocyte aging in osteoarthritis by protecting telomeres via SIRT3 and limiting p53 acetylation. The findings suggest kisspeptin-54 could help slow cartilage breakdown in OA.

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Serum and seminal kisspeptin were compared between fertile and infertile men with abnormal semen. The work aims to determine whether kisspeptin can serve as a biomarker for male infertility.

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Kisspeptin levels and gene variants were examined in women with PCOS, given its role in reproductive hormone regulation. Prior studies have been inconsistent, and this work aims to clarify the relationship.

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First-trimester serum kisspeptin was evaluated as a predictor of pregnancy complications. The work aims to determine whether this biomarker can identify women at higher risk early in pregnancy.

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Kisspeptin slowed growth of pterygium cells by blocking chemokine ligands in the microenvironment. The findings may support new biomarkers and treatments for this common eye condition.

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Kisspeptin improved myasthenia gravis in a mouse model by rebalancing Th1, Th17, and Treg cells and inhibiting NF-kappaB. The results suggest kisspeptin may influence autoimmune disease through neuroendocrine–immune crosstalk.

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Kisspeptin-54 reduced stroke damage in mice by restoring the blood-brain barrier via GATA-4 and occludin, cutting infarct size and improving neurological function. The KISS1/GPR54 pathway may be a therapeutic target for ischemic stroke.

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Kisspeptin affects cancer cell migration and controls the reproductive axis. The review summarizes current knowledge on its physiology and potential clinical uses.

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The kisspeptin receptor system is involved in reproduction, cancer, diabetes, and heart disease. The article reviews methods for finding agonists and antagonists and discusses challenges and future directions for drug development.

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Placentas from COVID-19 pregnancies in South Africa had higher kisspeptin expression and more inflammation and vascular problems. The findings support ongoing monitoring of mothers and babies after COVID-19 during pregnancy.

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Intranasal kisspeptin quickly raised gonadotropin levels in humans, offering a non-invasive way to stimulate reproductive hormones. The approach could improve patient acceptance for treating reproductive disorders.

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Kisspeptin activates reproductive hormones and brain regions involved in sexual and emotional processing, making it a candidate for treating low sexual desire. Better delivery methods and understanding of sex-specific effects are needed before clinical use.

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Kisspeptin increased reproductive hormones in humans but did not change anxiety levels. The results clarify that kisspeptin's clinical potential lies in reproductive and psychosexual disorders rather than anxiety.

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PFAS exposure was linked to metabolic biomarkers in Spanish adolescents, with kisspeptin possibly involved. The work explores how these chemicals may disrupt the endocrine–metabolic axis.

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Intravenous kisspeptin increased oxytocin levels in healthy adults, with a stronger effect in women. The results support kisspeptin as a possible provocative test for oxytocin deficiency.

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Serum kisspeptin, NKB, and GABA were altered in Chinese women with PCOS and linked to hormone profiles. The work explores whether these markers could help characterize or diagnose PCOS.

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Infertile men with low sperm count had lower kisspeptin and free testosterone and higher LH and FSH. A KISS1 gene variant was more common in infertile men, suggesting kisspeptin may be a marker for male reproductive health.

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Kisspeptin regulates reproductive behavior and emotional state through brain regions beyond the hypothalamus. The evidence supports exploring kisspeptin-based therapies for reproductive and psychosexual disorders.

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Kisspeptin, originally identified as a metastasis suppressor, is now known as a key regulator of puberty and GnRH release. The chapter discusses its distribution and role in reproduction across rodents, fish, and birds.

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Kisspeptin stimulates GnRH release and is central to puberty, adult reproduction, and reproductive aging in female mammals. The chapter reviews its role in controlling the hypothalamic–pituitary–gonadal axis and its therapeutic potential.

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GnRH injection was tested for its effect on kisspeptin levels in girls with suspected precocious puberty. The pilot study explores whether GnRH suppresses kisspeptin via negative feedback and how kisspeptin relates to other pubertal hormones.

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Liposomes coated with a kisspeptin analog targeted breast cancer cells via GPR54 and improved doxorubicin delivery, extending survival in tumor-bearing mice. The approach could offer a new way to target breast cancer with chemotherapy.

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Early puberty in patients with primary adrenal insufficiency due to MC2R mutations was evaluated. The work explores how the melanocortin system and leptin influence GnRH neurons and pubertal timing.

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Genetic causes of central precocious puberty were analyzed in 90 patients, including MKRN3, DLK1, KISS1, KISS1R, and MECP2. The study provides a molecular and clinical overview of CPP in this cohort.

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Chronic nasal kisspeptin-54 improved mood-related symptoms in rats with Parkinson's disease, partly through amygdaloid GABA. The findings suggest kisspeptin could help address depression and anxiety in Parkinson's.

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Kisspeptin-10 and its analogs reduced cervical cancer cell growth and migration by modulating kinase signaling. The analogs bound the kisspeptin receptor and showed promise as potential therapeutic agents for cervical cancer.

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A meta-analysis examined FTO and KISS1 gene variants and their link to PCOS in Asian populations. The work aims to clarify whether these polymorphisms increase PCOS risk.