Sleep Peptides
4Delta sleep-inducing peptide (DSIP) and related compounds are researched for their effects on sleep architecture, circadian rhythm regulation, and overall sleep quality. This category also includes supportive compounds like Melatonin.
DSIP
Delta Sleep-Inducing Peptide — a nine-amino-acid peptide originally found in rabbit brain during sleep research. Promotes deep, restorative sleep (stage 3 sleep) while also helping with stress, pain perception, and cell damage from stress. One of the few peptides that specifically targets sleep quality rather than just causing drowsiness.
Melatonin
The main hormone your brain makes to control your sleep-wake cycle. It rises in response to darkness and helps you fall asleep. Also acts as a powerful antioxidant. Production drops with age, which can contribute to sleep problems in older adults. One of the most widely used supplements globally, available over-the-counter in the US.
Pinealamin
A peptide complex extracted from the pineal glands of young animals (typically calves), developed by Vladimir Khavinson's group as a tissue-specific bioregulator for the pineal gland. Promoted for sleep regulation, melatonin support, and age-related circadian rhythm decline. A complex mixture of short peptides rather than a single defined molecule, which differentiates it from synthetic Khavinson tripeptides like pinealon.
Pinealon
A short three-amino-acid peptide (Glu-Asp-Arg) developed by Russian researcher Vladimir Khavinson as a brain bioregulator targeting the pineal gland and broader nervous system. Promoted for circadian rhythm regulation, neuroprotection, and supporting age-related cognitive function. Sits in the same Khavinson bioregulator family as epithalon, cortagen, vilon, and AEDG. Most evidence is from Russian research and animal studies — rigorous Western clinical trials are limited.