Peptide Research Database
Research-backed information on peptides — dosage, half-life, risks, and the latest peer-reviewed studies from PubMed.
Cerebrolysin
A porcine brain-derived peptide preparation containing a standardized mixture of low-molecular-weight neuropeptides and free amino acids. One of the most widely used neurotrophic treatments globally, approved in over 40 countries for stroke recovery, traumatic brain injury, and neurodegenerative diseases. Mimics the action of endogenous neurotrophic factors (BDNF, NGF, CNTF) to promote neuronal survival, synaptic plasticity, and neurogenesis.
Cortagen
A short synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Pro) developed by the Khavinson Institute in Russia. Designed to normalize brain cortex function by modulating gene expression in cortical neurons. Part of the Khavinson peptide bioregulator family alongside Epithalon and Vilon. One of the few peptides specifically formulated for cortical brain function optimization, available in both injectable and oral/sublingual forms.
Dihexa
A hexapeptide derivative of angiotensin IV reported to be up to 10 million times more potent than BDNF at enhancing cognitive function in animal models. One of the most discussed nootropic peptides for memory enhancement and neuroplasticity. Acts through the hepatocyte growth factor (HGF)/c-Met receptor system rather than traditional neurotransmitter pathways, representing a novel mechanism for cognitive enhancement.
Humanin
A 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the 16S rRNA gene of mitochondrial DNA. Related to MOTS-c but with distinct cytoprotective mechanisms. Protects cells against oxidative stress, apoptosis, and age-related degeneration by interacting with BAX (pro-apoptotic protein) and IGFBP-3. One of the most studied peptides in longevity research, with evidence of declining levels in aging tissues.
Oxytocin
A 9-amino-acid neuropeptide produced in the hypothalamus, known as the 'love hormone' for its central role in social bonding, trust, empathy, and pair bonding. Also essential for labor (stimulates uterine contractions) and breastfeeding (triggers milk letdown). FDA-approved as Pitocin for labor induction, with growing use of intranasal formulations for social-behavioral and mental health applications.
P21 (P021)
A small molecule peptide mimetic derived from ciliary neurotrophic factor (CNTF). Promotes neurogenesis, protects existing neurons, and inhibits tau hyperphosphorylation — the pathological process that forms neurofibrillary tangles in Alzheimer's disease. One of the few peptides specifically targeting neurodegenerative mechanisms, representing a potential therapeutic approach for Alzheimer's disease and age-related cognitive decline.
Selank
A synthetic heptapeptide based on the endogenous immunomodulatory peptide tuftsin, with a Pro-Gly-Pro extension for enzymatic stability. Developed at the Russian Academy of Sciences as both an anxiolytic and a nootropic. Uniquely combines benzodiazepine-like anti-anxiety effects (without sedation or addiction) with cognitive enhancement through BDNF upregulation and immune modulation through its tuftsin core.
Semax
A synthetic analogue of the ACTH(4-10) fragment with a Pro-Gly-Pro C-terminal extension for stability. Developed in Russia as a nootropic and neuroprotective agent, approved there for clinical use in cognitive disorders and TBI recovery. Enhances cognition, memory consolidation, and sustained attention through upregulation of NGF and BDNF in the hippocampus and cortex.
Recent Research
A novel exopolysaccharide from Lactiplantibacillus plantarum H6 improves cholesterol metabolism via Muribaculum-mediated activation of the enterohepatic FXR-FGF15 axis.
Reactive Carbonyl Species Mediate Isothiocyanate Signaling Pathway in Arabidopsis thaliana Guard Cells.
Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy?
Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy?
Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice.